The Immune System

©2003 Theresa Goodell

 

The immune system is a complex of organs--highly specialized cells and even a circulatory system separate from blood vessels--all of which work together to clear infection from the body. The organs of the immune system, positioned throughout the body, are called lymphoid organs.  Lymphatic vessels and lymph nodes are the parts of the special circulatory system that carries lymph, a transparent fluid containing white blood cells, chiefly lymphocytes

Lymph bathes the tissues of the body, and the lymphatic vessels collect and move it eventually back into the blood circulation. Lymph nodes dot the network of lymphatic vessels and provide meeting grounds for the immune system cells that defend against invaders. The spleen, at the upper left of the abdomen, is also a staging ground and a place where immune system cells confront foreign microbes.

All immune cells exit the lymphatic system and eventually return to the bloodstream. Once in the bloodstream, lymphocytes are transported to tissues throughout the body, where they act as sentries on the lookout for foreign antigens.

Organs of the Immune System

Tonsils

 

Tonsils are the two masses on the back of the throat. Tonsils and adenoids are near the entrance to the breathing passages where they can catch incoming germs, which cause infections.

Adenoids

 

Adenoids are high in the throat behind the nose and the roof of the mouth (soft palate) and are not visible through the mouth without special instruments.

Spleen

 

A spongy, soft organ about as big as a person's fist, is located in the upper left part of the abdomen, just under the rib cage. The splenic artery brings blood to the spleen from the heart. Blood leaves the spleen and moves to the liver.

Appendix

 

The appendix looks somewhat similar to the tonsils in that it has crypts penetrating from the gut opening deep into the tissue and around these are numerous lymphoid follicles.

Peyer's Patches

Lymphoid follicles similar to lymph nodes or the tonsils, located especially in the lower small intestine. They contain white blood cells, defend against invading bacteria and try to prevent inadequately digested food particles from crossing the gut wall and entering the blood.

Thymus

 

In the thymus gland lymphoid cells undergo a process of maturation and education prior to release into the circulation. This process allows T cells to develop the important attribute known as self tolerance.

Lymph Nodes

Lymph nodes are small bean shaped structures lying along the course of lymphatics. They are aggregated in particular sites such as the neck, axillae, groins and para-aortic region. Knowledge of the sites of lymph nodes is important in physical examination of patients. Lymph nodes have two main functions: 1. phagocytic cells act as filters for particulate matter and micro-organisms 2. antigen is presented to the immune system

Bone Marrow

All the cells of the immune system are derived from stem cells in the bone marrow. The bone marrow is the site of origin of red blood cells, white cells (including lymphocytes and macrophages) and platelets.

The spleen is made up of the white pulp and the red pulp, each with different functions. The white pulp is part of the infection-fighting (immune) system. It produces white blood cells called lymphocytes, which in turn produce antibodies (specialized proteins that protect against invasion by a foreign substance). The red pulp filters the blood, removing unwanted material. The red pulp contains other white blood cells called phagocytes that ingest microorganisms, such as bacteria, fungi, and viruses. It also monitors red blood cells, destroying those that are abnormal or too old or damaged to function properly. In addition, the red pulp serves as a reservoir for different elements of the blood, especially white blood cells and platelets (cell-like particles involved in clotting). However, releasing these elements is a minor function of the red pulp.

Cells of the Immune system

All immune cells exit the lymphatic system and eventually return to the bloodstream. Once in the bloodstream, lymphocytes are transported to tissues throughout the body, where they act as sentries on the lookout for foreign antigens.

 

Cells of the Immune system

Lymphocytes

There are two broad sub-types of lymphocyte. B and T cells are derived from the bone marrow and circulate in the blood and through body tissues Each B cell and T cell is specific for a particular antigen. What this means is that each is able to bind to a particular molecular structure.

B Cells

B cells give rise to plasma cells which are  mature B lymphocytes  specialized for antibody (immunoglobulin) production

Antibodies

The stimulated B cell undergoes repeated cell divisions, enlargement and differentiation to form a clone of antibody secreting plasma cells. That antibody then binds to the bacteria making them easier to ingest by white cells. Antibody combined with a plasma component called "complement" may also kill the bacteria directly.

T Cells

T cells undergo a process of maturation in the thymus gland and respond to antigens


 

 

Macrophages and dendritic cells

These cells are derived from the bone marrow and have a variety of functions in the immune response:

  • phagocytosis (To eat the antigen) The phagocyte surrounds and kills the invading microorganism

  • secretion of cytokines:small secreted proteins which mediate and regulate immunity, inflammation, and hematopoiesis.

  • antigen presentation: Antigen processing and presentation are processes that occur within a cell that result in fragmentation  of proteins.